ncRNA name | VEGFR2 shRNA |
ncRNA Category | shRNA |
Disease name | retinopathy of prematurity (ROP) |
Species | Homo sapiens |
Tissues/Cell_line | human RPE cell line ARPE-19 |
Methods | shRNA knockdown, MTT assay, BrdU incorporation assay, transwell assay, qRT-PCR, ELISA, Western blot |
Expression pattern | associated |
Functional description | Gremlin promotes RPE cell proliferation, migration and VEGF production possibly via activating VEGFR2-Akt-mTORC2 signaling.Gremlin-induced VEGFR2 phosphorylation, cell proliferation, migration and VEGF production were almost abolished in VEGFR2-silenced cells. |
PubMed ID | 27894090 |
Year | 2017 |
Title | Gremlin promotes retinal pigmentation epithelial (RPE) cell proliferation, migration and VEGF production via activating VEGFR2-Akt-mTORC2 signaling. |
Drug-related ncRNA | NA |
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